Insulin secretion and its association with physical activity, fitness and screen time in children

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Insulin secretion and its association with physical activity, fitness and screen time in children

Published on Oct. 16, 2013

Objective To determine the independent associations of moderate to vigorous physical activity (MVPA), fitness, screen time, and adiposity with insulin secretion in children.

Design and Methods Caucasian youth (n = 423/630), 8-10 years old, with at least one obese biological parent, were studied (QUALITY cohort). Insulin secretion was measured using HOMA2-%B, area under the curve (AUC) of insulin to glucose over the first 30 minutes (AUC I/Gt30min) of the OGTT and AUC I/Gt120min over 2 hours. Fitness was measured by VO2peak; percent fat mass (PFM) by DXA; 7-day MVPA by accelerometry; self-reported screen time included television, video game, or computer use. Models were adjusted for age, sex, season, puberty, PFM, and insulin sensitivity [IS] (HOMA2-IS, Matsuda-ISI).

Results PFM was strongly associated with insulin secretion, even after adjustment for IS: for every 1% increase in PFM, insulin secretion increased from 0.3% to 0.8% across indices. MVPA was negatively associated with HOMA2-%B (P < 0.05), but not with OGTT-derived measures. Fitness was negatively associated with AUC I/Gt120min (P < 0.05). Screen time showed a trend toward higher HOMA2-%B in girls (P = 0.060).

Conclusion In children with an obese parent, lower insulin secretion is associated with lower adiposity, higher MVPA, better fitness, and possibly reduced screen time.

Author(s)

M. Henderson ^{1, 2, 3}

K. Gray-Donald ^{1, 4}

R. Rabasa-Lhoret ^{5, 6, 7}

J. -P. Bastard ^{8, 9 ,10}

T. A. Barnett ^{3, 11}

A. Benedetti ^{1, 12, 13}

Chaput ¹⁴

A. Tremblay ¹⁵

M. Lambert ¹⁶

Institution(s)

1

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada

2

Division of Endocrinology, Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montreal, Quebec, Canada

3

Centre de Recherche du CHU Sainte Justine, Montréal, Quebec, Canada

4

Department of Dietetics and Human Nutrition, McGill University, Montréal, Quebec, Canada

5

Department of Nutrition, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada

6

Institut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, Canada

7

Montreal Diabetes Research Center (MDRC), Montreal, Quebec, Canada

8

AP-HP, Hôpital Tenon, Service de Biochimie et Hormonologie, Paris, France

9

Inserm, Paris, France

10

UPMC-Paris 6, Paris, France

11

Department of Exercise Science, Concordia University, Montréal, Quebec, Canada

12

Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre, Montreal, Quebec, Canada

13

Department of Medicine, McGill University, Montréal, Quebec, Canada

14

Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada

15

Department of Kinesiology, Université Laval, Quebec, Canada

16

Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montréal, Quebec, Canada

Journal

Obesity

Research Study Abstract